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HomeHealthMedicineLower Hormone Levels Linked to Risk of Sleep Apnea

Lower Hormone Levels Linked to Risk of Sleep Apnea

Women with decrease ranges of two intercourse hormones could also be at elevated danger of experiencing obstructive sleep apnea (OSA) in center age, in accordance with a brand new examine.

The findings, published June 22 in PLOS ONE, confirmed that postmenopausal girls with double the common estrogen focus had as a lot as a 23% lower within the odds of loud night breathing. Women with double the common progesterone focus had a 9% lower within the odds of loud night breathing.

“Our study is important, as it is another building block on the way to individualized hormone substitution for postmenopausal women,” stated Kai Triebner, PhD, postdoctoral fellow on the University of Bergen, Norway, and senior creator of the article. “The observed associations had already been suspected by smaller studies, and now we finally were able to prove them in a large population-based cohort with very precise measurements of their hormone status.”

OSA is marked by loud night breathing, irregular respiration, and/or gasping. The situation can result in poor sleep high quality and is related to an elevated danger of cardiovascular circumstances, together with ischemic heart disease and stroke.

Previous research have proven that estrogen and progesterone mitigate the signs of OSA. Triebner and his colleagues sought to judge the protecting affiliation between hormones and sleep on a inhabitants stage.

The new examine included 774 girls (age, 40–67 years) from the 2010–2012 European Community Respiratory Health Survey. The girls responded to 2 questionnaires about respiratory well being and sleep and gave blood for hormone evaluation of progesterone and three sorts of estrogen: 17β-estradiol, estrone, and estrone 3-sulfate.

Women with hormonal irregularities, similar to endometriosis, and people taking exogenous intercourse hormones by substitute remedy or contraception had been excluded from the examine.

Among the whole group, 551 reported loud night breathing. Of these, 411 had extra signs of OSA, similar to irregular respiration, gasping, or a disturbing snore. Triebner and his colleagues decided the common estrogen and progesterone concentrations of all girls within the examine. Women with double the common estrogen focus had a 19% lower in odds of loud night breathing.

With regard to particular person types of estrogen, girls with double the common serum focus of 17β-estradiol, estrone, and estrone 3-sulfate had a 17% to 23% lower in odds of respiration irregularity. Women with double the common serum focus of progesterone had a 9% lower within the odds of loud night breathing and a 12% lower within the odds of waking up with a choking or gasping sensation.

“By adjusting our model for BMI [body mass index] and alcohol consumption, we found that the results of the study [the effect of hormones on the risk of OSA] were not influenced,” Triebner informed Medscape Medical News.

Triebner’s workforce didn’t give girls exogenous estrogen or progesterone to watch particular person modifications in sleep habits.

“The path to a great hormone replacement therapy is just not but paved,” Triebner stated. “What may be beneficial for one woman might be actually harmful to the other. The next steps are considerably more research on how to properly administer an individualized hormone therapy to women.”

Vincent Joseph, PhD, a sleep researcher at Laval University, Quebec, Canada, stated the findings had been unsurprising.

“The mechanisms have been addressed, at least partially, in animal studies, showing effects on key structures in the brain and elements of the peripheral nervous system that are involved in the control of respiration,” Joseph, who was not concerned within the examine, informed Medscape.

However, the outcomes present a a lot stronger case to help the hyperlink between the variation of hormone ranges and sleep apnea in girls, Joseph added.

Triebner and Joseph reported no related monetary relationships.

PLoS One. Published on-line June 22, 2022. Full text

Arianna Sarjoo is an intern at Medscape and a biology main at Boston University.

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